Is it safe to have anal sex while pregnant? Is this safe while pregnant? for an expectant mom, can be especially harmful and difficult to treat. Ask your provider if it's OK to have anal sex. Anal sex is sex that involves the penis and the anus. Anal sex may be unsafe during pregnancy because the anus is. If you enjoy anal sex, you may be wondering if you have to give it up during pregnancy, or take any special safety precautions. Our expert has the answers.